Posts in Disease Classification Index (DCI)
Altered type II interferon precedes autoantibody accrual and elevated type I interferon activity prior to systemic lupus erythematosus classification

This study shows immune changes appear years before lupus is diagnosed: “type II interferon” and certain blood signals rise first, autoantibodies build next, and “type I interferon” spikes closest to diagnosis; combining these markers accurately flags high-risk individuals for earlier evaluation.

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Discerning risk of disease transition in relatives of systemic lupus erythematosus patients utilizing soluble mediators and clinical features

This study followed relatives of people with lupus and found those who later developed the disease already had higher “inflammation” signals in blood and lower “calming” signals; two markers, SCF (higher) and TGF-β (lower), best predicted who would transition, enabling earlier referral and prevention efforts.

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