This review highlights the need for predictive biomakers in SLE. A soluble mediator score showed high predictivity of impending flare in diverse population, offering a promising tool for early flare detection and intervention
Read MoreThis study evaluated whether immune mediators predicts lupus flares. Using plasma samples and machine learning algorithm, 31 mediators ditinguished pre-flare from stable state. A refined lupus flare prediction index achieved high sensitivity and specificity supporting its use as a predictive tool for early flare detection and lupus management.
Read MoreThis study assessed baseline and follow-up plasma levels of 52 soluble mediators in African American SLE patients. Results showed 31 elevated Immune mediator preceding disease flare, aiding in personalized flare prediction and intervention strategies
Read MoreThis study evaluated the changes in plasma concentrations of soluble mediators that precede clinically defined disease flares. Findings showed that shift in inflammatory and regualatory cytokines precedes lupus flares, suggesting that soluble mediators can serve as predictive biomakers, enabling earlier intervention and more precise monitoring of disease activity.
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