This study assessed whether select Patient-reported outcomes enhance flare and disease activity indexes (L-DAI & L-FRI). Results showed PRO domains improves prediction and screening performance in lupus, supporting integration into SLE management
Read MoreThis study refined the flare risk index using immune mediators profiles in lupus patients. A subset of 11 mediators predicted risk of imminent flare with high sensitivity and specificity, enabling early intervention and improved disease management.
Read MoreThis study validated the utility of the flare risk index. 11 immune mediators shows strong predictive power for lupus flares, including differentiation of mild-moderate and severe flare risk.
Read MoreThis study evaluated whether immune mediators predicts lupus flares. Using plasma samples and machine learning algorithm, 31 mediators ditinguished pre-flare from stable state. A refined lupus flare prediction index achieved high sensitivity and specificity supporting its use as a predictive tool for early flare detection and lupus management.
Read MoreThis study assessed baseline and follow-up plasma levels of 52 soluble mediators in African American SLE patients. Results showed 31 elevated Immune mediator preceding disease flare, aiding in personalized flare prediction and intervention strategies
Read MoreThis study evaluated the changes in plasma concentrations of soluble mediators that precede clinically defined disease flares. Findings showed that shift in inflammatory and regualatory cytokines precedes lupus flares, suggesting that soluble mediators can serve as predictive biomakers, enabling earlier intervention and more precise monitoring of disease activity.
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